A Personalized Health & Longevity Blueprint
Prepared for:
Client Name
Date:
September 14, 2025
This report provides a detailed analysis of your biomarkers against longevity-focused targets, designed to offer actionable feedback on your test results. Our analysis indicates that the most significant finding is a state of high systemic inflammation, which appears to be driven by an underlying and equally important issue: early signs of metabolic dysfunction.
Your elevated hs-CRP (a marker of inflammation) is a key finding, but it is likely a symptom of the foundational issue of insulin resistance, evidenced by your high Fasting Insulin and HOMA-IR score. This combination is driving a high burden of atherogenic particles (Apolipoprotein B), which increases cardiovascular risk. While managing inflammation is important, addressing the root cause through metabolic improvements should be the central focus of your health strategy. The analysis has also identified key opportunities for optimization in nutrient status, including low levels of Vitamin D, Magnesium, Zinc, and Ferritin.
Our analysis compares your results to ideal values for longevity and healthspan, backed by research into what blood markers correspond with reduced disease risk. Our targets are aggressive by nature, so please remember this when looking through the results and action plan.
Disclaimer: This is a data analysis product, not medical advice. Do not make any changes to your health regimen based on this report without first consulting your physician. Our intent is for this data to facilitate a productive discussion between you and your doctor.
C
A high Fasting Insulin level and HOMA-IR score indicate early signs of insulin resistance, a foundational area requiring attention.
C
Your Apolipoprotein B and LDL Cholesterol are high, suggesting a large number of plaque-forming particles and an elevated long-term risk.
C-
Systemic inflammation (hs-CRP) is high. Additionally, multiple key nutrients, including Vitamin D, Magnesium, and Zinc, are suboptimal.
A
Your key organ health markers for the liver and kidneys are excellent, indicating robust function and providing a strong foundation for overall health.
Chronological Age: 40
Your biological age is significantly younger than your chronological age. This is an excellent result and a major strength, indicating that your current lifestyle habits are having a protective effect on your aging process.
33.36
Your results for Fasting Insulin (18.5 µIU/mL) and the calculated HOMA-IR score (3.47) represent the most important findings in this report. These markers point to the presence of insulin resistance, a condition where your body's cells don't respond efficiently to the hormone insulin. This is a foundational issue that can drive many other health concerns, and addressing it is the most powerful lever you have for improving your long-term health.
It's common to see a normal Fasting Glucose (yours is an optimal 75 mg/dL) and assume metabolic health is perfect. However, your high Fasting Insulin level reveals what is happening "behind the scenes." This is the earliest detectable stage of metabolic dysfunction.
Think of it like a conversation where your cells have started to not listen very well. In response, your pancreas must "shout"—that is, produce a much higher amount of insulin—just to get the cells to perform their normal function of taking up glucose from the blood. Your high insulin level is a direct measurement of this compensatory "shouting." This state of high insulin with normal blood sugar often precedes any noticeable rise in long-term markers like HbA1c or fasting glucose by many years.
This makes your current situation a crucial window of opportunity. By focusing on strategies to resensitize your cells to insulin, you can reduce the workload on your pancreas and address the root cause of the inflammation (high hs-CRP) and atherogenic lipid patterns (high ApoB) seen elsewhere in this report before they progress further.
Your Apolipoprotein B is high at 111 mg/dL, indicating a large number of plaque-forming particles in your bloodstream. This is a direct causal factor for atherosclerosis. This risk is compounded by your elevated hs-CRP (2.3 mg/L), a marker of systemic inflammation that can contribute to arterial plaque instability. These two markers together create a pro-atherosclerotic environment.
Your results show suboptimal levels of several critical micronutrients, including Vitamin D (34.0 ng/mL), RBC Magnesium (4.5 mg/dL), Zinc (74.0 mcg/dL), and Ferritin (22.0 ng/mL). These nutrients are essential cofactors for thousands of processes, including immune function, energy production, and hormone synthesis. Correcting these deficiencies is a high-impact opportunity.
Despite the priorities listed, your report shows several areas of excellent health. Your kidney function (eGFR of 101) is outstanding, and your liver enzymes (ALT and AST) are optimally low, indicating healthy organ function. Furthermore, your hormonal profile appears well-balanced for a female, and your primary thyroid marker (TSH) is in a great range. These strengths provide a solid foundation from which to address the identified areas for improvement.
This area presents a clear and important opportunity for improvement. Your markers indicate that your body is overproducing insulin to keep your blood sugar in a normal range. This condition, known as insulin resistance, is a critical leverage point for improving nearly every other aspect of your health, from cardiovascular risk to hormonal balance.
Optimal
<5.0
Standard
<18.4
Your Result
18.5
Fasting insulin measures the amount of insulin in your blood after an overnight fast. Your high level, even with normal glucose, is the earliest and most sensitive marker for insulin resistance. This is a top priority for intervention.
Optimal
<1
Standard
N/A
Your Result
3.47
HOMA-IR measures insulin resistance by calculating the relationship between fasting glucose and insulin. Values below 1.0 indicate excellent insulin sensitivity. Your value of 3.47 confirms a degree of insulin resistance.
Optimal
75-85
Standard
65-99
Your Result
75
Your fasting glucose is optimally controlled. This is a strength, but it's important to recognize that this is being achieved at the cost of very high insulin levels. Improving insulin sensitivity will allow you to maintain this excellent glucose control with much lower insulin output.
Optimal
<5.0%
Standard
<5.7%
Your Result
5.3%
HbA1c provides a three-month average of your blood sugar levels. Your level is suboptimal and reflects a trend towards higher average blood glucose, which is consistent with the underlying insulin resistance.
Optimal
<5.5
Standard
2.5-7.0
Your Result
4.0
Uric acid can be a marker of metabolic health, with higher levels often linked to insulin resistance. Your level is optimal, which is a positive data point in this category.
This section reveals a high burden of atherogenic, or plaque-forming, particles, which is strongly linked to the early signs of metabolic dysfunction seen elsewhere in this report. While improving your metabolic health is the most important foundational strategy, your Apolipoprotein B and LDL Cholesterol levels are high enough that direct intervention is likely needed to maximize your risk reduction for future atherosclerotic cardiovascular disease (ASCVD) events. This approach ensures that you are addressing both the root cause (metabolic health) and the immediate risk (high particle burden) simultaneously.
Optimal
<80
Standard
<90
Your Result
111
ApoB is a direct measure of the number of atherogenic (plaque-forming) particles in your blood. Your high level is a more accurate predictor of cardiovascular risk than LDL cholesterol alone and should be a primary target for reduction.
Optimal
<70
Standard
<100
Your Result
157
While LDL cholesterol is a less accurate marker than ApoB, your high level is consistent with your overall lipid profile. It underscores the need for intervention to reduce the amount of cholesterol available to form plaque in the arteries.
Optimal
<80
Standard
<150
Your Result
148
Triglycerides are a type of fat in the blood and a key marker of metabolic health. Your level is on the high end of the standard range and well above optimal, which is a strong indicator of insulin resistance and is linked to increased cardiovascular risk.
Optimal
<1.0
Standard
<3.0
Your Result
2.6
This ratio is calculated by dividing your Triglycerides (148 mg/dL) by your HDL (57 mg/dL). A ratio above 2.0 strongly suggests insulin resistance and a higher concentration of small, dense LDL particles, which are more atherogenic.
Optimal
>60
Standard
>49
Your Result
57
Often called "good cholesterol," HDL helps remove cholesterol from arteries. Your level is good, but not yet optimal. Raising it above 60 mg/dL would be even more protective and often occurs naturally as insulin sensitivity improves.
This area is a key concern. Your marker for systemic inflammation (hs-CRP) is high, which can accelerate aging and increase the risk of chronic disease. This is likely driven by the metabolic issues identified elsewhere in the report. Addressing the root cause is the most effective way to lower this inflammation.
Optimal
<0.5
Standard
<3.0
Your Result
2.3
High-sensitivity C-reactive protein is a key marker of systemic inflammation. Your high level indicates a state of chronic, low-grade inflammation, which is a root cause of most age-related diseases. This is a critical marker to lower.
Optimal
<9.0
Standard
<11.0
Your Result
9.5
An amino acid that, when elevated, can be an independent risk factor for cardiovascular disease. Your level is suboptimal and should be a focus for optimization, typically through B-vitamin support.
Optimal
1500-3000
Standard
850-3900
Your Result
1984
These are important white blood cells for the adaptive immune system. Your robust count is a sign of a resilient immune system, a cornerstone of healthy aging.
Optimal
3.8-10.8
Standard
3.8-10.8
Your Result
6.4
Your total white blood cell count is squarely in the normal range, indicating no signs of acute infection or chronic immune activation.
Optimal
11.0-15.0%
Standard
11.0-15.0%
Your Result
12.7%
RDW (Red Cell Distribution Width) measures the variation in red blood cell size. An optimal RDW is associated with lower mortality risk. Your level is within the optimal range.
Your hormonal profile appears balanced and healthy. Key markers like testosterone and estradiol are at levels consistent with a healthy, premenopausal female, and your thyroid function is excellent. This provides a strong hormonal foundation.
Optimal
20-60
Standard
15-70
Your Result
46.0
Total testosterone in women is crucial for libido, bone density, and muscle mass. Your level is solidly within the optimal range for a female.
Optimal
2-8
Standard
1-9
Your Result
5.6
This is the bioavailable, active form of testosterone. Your level is optimal, indicating healthy hormonal activity.
Optimal
30-100
Standard
20-130
Your Result
32.0
SHBG binds to sex hormones, making them inactive. Your level is optimally low for a female, which allows for healthy levels of free, active hormones. This is an excellent result.
Optimal
0.5-2.0
Standard
0.4-4.5
Your Result
0.75
TSH is the primary marker of thyroid function. Your result is solidly in the optimal range, indicating your thyroid is functioning well. This is a significant strength.
Estradiol (E2): Your result of 231.0 pg/mL is a normal level for a premenopausal woman, likely indicating you were near the mid-point of your menstrual cycle at the time of the blood draw.
LH & FSH: Your LH of 12.6 mIU/mL and FSH of 3.7 mIU/mL are also consistent with normal fluctuations within a menstrual cycle.
DHEA-Sulfate: Your result of 443.0 mcg/dL is at the high end of the normal range (61-442 mcg/dL). DHEA is a precursor hormone; levels at the very top of the range are worth monitoring over time but are not an immediate concern.
IGF-1: Your result of 148.0 ng/mL is in the optimal range (100-160 ng/mL). IGF-1 is a key hormone for cellular repair, and levels in this "sweet spot" are associated with healthy aging.
Cortisol: Your morning cortisol level of 12.5 mcg/dL is well within the normal range (4.6-20.6 mcg/dL), suggesting a healthy and resilient stress-response system.
Free T3 & Free T4: Your Free T3 of 3.5 pg/mL and Free T4 of 1.1 ng/dL are both optimal, indicating excellent thyroid hormone production and conversion.
This area is a significant strength. Your markers for kidney and liver function are excellent, indicating that your vital organs are currently healthy and resilient. Maintaining this solid foundation is key as you work on improving your metabolic health to prevent future strain on these systems.
Optimal
>90
Standard
>60
Your Result
101
eGFR (estimated Glomerular Filtration Rate) is the best measure of kidney function. Your value is outstanding and indicates robust kidney health.
Optimal
0.7-0.9
Standard
0.6-1.26
Your Result
0.77
Creatinine is a waste product from muscle metabolism used to calculate eGFR. Your level is optimally low, consistent with your excellent eGFR score.
Optimal
<25
Standard
6-29
Your Result
13
ALT is a key liver enzyme. Your level is optimally low, reflecting minimal liver stress and no signs of non-alcoholic fatty liver disease (NAFLD), which is a positive finding.
Optimal
<25
Standard
10-40
Your Result
13
AST is another liver enzyme. Your level is optimally low, indicating a healthy liver free from inflammation or damage, which is vital for detoxification and overall metabolic health.
Optimal
40-70
Standard
31-125
Your Result
71
Alkaline Phosphatase (ALP) is an enzyme related to the liver and bones. Your level is in the optimal range, further confirming the excellent health of your organ systems.
Optimal
<0.8
Standard
N/A
Your Result
0.6
Bilirubin is a potent antioxidant. Your level is optimal, which is associated with reduced risk of cardiovascular and metabolic diseases.
This analysis reveals that your nutritional status has several clear, high-impact areas for improvement. You have suboptimal levels of multiple key vitamins and minerals that are crucial for energy, immune function, and metabolic health. Correcting these is a foundational step in your overall health optimization plan.
Optimal
40-80
Standard
30-100
Your Result
34.0
Vitamin D is critical for immune function and bone health. Your level is suboptimal. Achieving an optimal level (40-80 ng/mL) is associated with reduced risk for a wide range of chronic diseases and is a key area for improvement.
Optimal
6.0-6.5
Standard
N/A
Your Result
4.5
RBC magnesium is a more accurate measure of the body's magnesium stores than a standard serum test. Your level is low. Optimal magnesium is crucial for energy production, DNA repair, and improving insulin sensitivity.
Optimal
80-120
Standard
60-130
Your Result
74
Zinc is an essential mineral for immune function, DNA synthesis, and testosterone production. Your level is low and bringing it into the optimal range is a key supportive step for overall health.
Optimal
40-170
Standard
16-232
Your Result
22
Ferritin reflects your body's long-term iron stores. Your level is low. While high ferritin can be a marker of inflammation, your result suggests your iron stores are genuinely low, which can impact energy levels and thyroid function.
Optimal
25-40%
Standard
16-45%
Your Result
38.0%
This measures the amount of iron readily available for use. Your level is optimal, indicating that while your long-term stores (Ferritin) are low, you have adequate iron in circulation for now.
Optimal
80.0-100.0
Standard
80.0-100.0
Your Result
95.5
MCV measures the average size of your red blood cells. Your level is on the high end of the normal range, which can sometimes be associated with B-vitamin status. This aligns with your suboptimal Homocysteine level.
Your markers show a clear path forward. The following strategy is designed to be comprehensive and impactful. It is essential to discuss this plan with your doctor to create a personalized approach and ensure it is safe and appropriate for you.
This is the most important area to focus on. Lowering your fasting insulin and HOMA-IR will have the largest downstream benefits, including reducing inflammation (hs-CRP) and atherogenic particles (ApoB). This requires a concerted effort focused on diet, exercise, and sleep.
Your diet is the most powerful tool for improving insulin sensitivity. The primary goal is to manage blood sugar levels and reduce the demand for insulin.
Exercise works on two crucial fronts: it helps dispose of current blood sugar and it builds a more resilient metabolic system for the future.
Sleep quality has a direct and immediate impact on insulin sensitivity. Even a single night of poor sleep can induce a state of temporary insulin resistance.
Your high ApoB and hs-CRP create a high-risk cardiovascular environment. The primary lever to pull here is improving your metabolic health, as outlined in step 1. As insulin sensitivity improves, your liver typically produces fewer atherogenic particles and systemic inflammation decreases.
Restoring optimal levels of key nutrients is a high-impact, foundational step that supports all other efforts. These micronutrients are critical for metabolic function, hormone production, and reducing inflammation.
To gain deeper insights and further refine your health strategy, we recommend considering the following diagnostics in consultation with your physician.
A CGM would be an exceptionally powerful tool for you. Given your high insulin and HOMA-IR, it would provide invaluable, real-time feedback on how specific foods, exercise, stress, and sleep impact your blood sugar. This personalized data can accelerate your progress in reversing insulin resistance.
Given your high ApoB and hs-CRP, it is prudent to assess your coronary artery health directly. A Coronary Artery Calcium (CAC) score is a non-invasive scan that measures existing calcified plaque. This can clarify your true risk and help guide the aggressiveness of treatment with your doctor.
Lipoprotein(a) is a largely genetic and independent risk factor for cardiovascular disease. As it was not included in your current panel, testing it is a critical next step to get a complete picture of your cardiovascular risk profile. Knowing this number is essential for determining the appropriate aggressiveness of your lipid-lowering strategy.
While your high hs-CRP suggests a need for anti-inflammatory support like fish oil, an Omega-3 Index test directly measures the percentage of EPA and DHA in your red blood cells. This test provides precise data to guide your supplementation, ensuring you reach the cardioprotective optimal level of >8%.
Based on your biomarker results, the following supplements could be considered to address your key health areas. The products shared are just examples; any high-quality brand is acceptable. Please discuss all new supplements with your physician.
Typical Dose: 500mg, 2-3 times per day with meals (Final dosage to be determined with your doctor). | Rationale: To directly address your high Fasting Insulin (18.5) and HOMA-IR (3.47). This compound has been studied for its ability to improve insulin sensitivity and glucose metabolism, serving as a powerful adjunct to diet and exercise.
Typical Dose: 2-4g EPA+DHA daily (Final dosage to be determined with your doctor). | Rationale: To help lower your high systemic inflammation (hs-CRP of 2.3). Optimal Omega-3 status is strongly associated with cardiovascular health and provides potent anti-inflammatory benefits.
Typical Dose: 400-500mg per day (Final dosage to be determined with your doctor). | Rationale: To raise your low RBC Magnesium (4.5 mg/dL) to optimal levels (>6.0 mg/dL). Magnesium is a critical cofactor for improving insulin sensitivity, blood pressure regulation, and energy production.
Typical Dose: 2000-5000 IU daily with food (Final dosage to be determined with your doctor). | Rationale: To raise your suboptimal Vitamin D level of 34 ng/mL into the optimal range (40-80 ng/mL). Vitamin D is crucial for immune regulation and has been linked to improved insulin sensitivity.
Typical Dose: 1 capsule daily (Final dosage to be determined with your doctor). | Rationale: To address your suboptimal Homocysteine level (9.5). Using methylated (active) forms of B12 and folate supports the body's methylation cycle, which is important for reducing this vascular risk factor.
Typical Dose: As directed by your physician based on follow-up testing. | Rationale: To help raise your low Ferritin level (22 ng/mL) into the optimal range (>40 ng/mL). Repleting iron stores is important for energy production, cognitive function, and thyroid health.
Disclaimer: Always consult your healthcare provider before adding or adjusting any supplements, especially when considering interactions with prescribed medications. The interventions discussed in this report require physician supervision.
This report provides a detailed, data-driven snapshot of your current health. The biomarkers clearly indicate that your most powerful lever for improving long-term health is to focus on reversing insulin resistance and lowering inflammation. While this may seem like a significant challenge, you have major strengths to build upon, including excellent organ function. Our analysis is designed to help you chase optimal levels based on cutting-edge research, not just "normal" lab ranges. These targets are aggressive by nature, so don't be discouraged by the results. Know that these markers are highly modifiable through the lifestyle and other interventions outlined in this report.
The information contained in this report is for informational and educational purposes only. The Kestrel Report is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read in this report.
The "optimal ranges" discussed are based on emerging longevity research and may differ from the "standard ranges" provided by clinical laboratories. The interventions and recommendations suggested are not intended to treat, cure, or prevent any disease. Any application of the material provided is at the reader's discretion and sole risk. Statements in this report have not been evaluated by the Food and Drug Administration.